S56. The Relation Between Hippocampal Volume and Allostatic Load is Moderated by Tanner Stage, Sex, and Adversity in Youth With Depression and Obesity

Stress and sex hormones impact hippocampal volume; imparting risk for neuropsychiatric disorders. Repetitive, chronic stress, such as that imparted by adverse childhood experience (ACE) exposure, can lead to systemic physiologic adaptations increasing disease risk, defined as allostatic load (AL). No human studies have examined the relation between hippocampal volume and AL as related to ACEs and sex in youth. Our work investigated the role of...