Issues in the determination of ‘responders’ and ‘non‐responders’ in physiological research

New Findings What is the topic for this review? We discuss the dichotomization of continuous‐level physiological measurements into ‘responders’ and ‘non‐responders’ when interventions/treatments are examined in robust parallel‐group studies. What advances does it highlight? Sample responder counts are biased by pre‐to‐post within‐subject variability. Sample differences in counts may be explained wholly by differences in mean response, even...