Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived mutations naturally presented as HLA class I ligands in HCCs.In-depth multi-omics analyses included whole exome and transcriptome sequencing to define individual...