MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Volume: 116, Issue: 27, Pages: 13480 - 13489
Published: May 24, 2019
Abstract
Significance IgA is the most abundantly produced antibody in the body (in humans, >5 g/d) and plays a crucial role in mucosal immunity. IgA forms a dimer that covalently associates with the joining (J) chain, which is essential for IgA transport into the gut. We show that MZB1 is required for the secretion of IgA, but not IgG, by antibody-secreting plasma cells. MZB1 mediates the stabilization of Igα heavy-chain–light-chain complexes and,...
Paper Details
Title
MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation
Published Date
May 24, 2019
Volume
116
Issue
27
Pages
13480 - 13489
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.