The mutational profile of IBC reveals higher mutational burden, deficiency of homologous recombination and NOTCH signalling

Background: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with elevated metastatic potential. In the past, we have identified a gene expression profile that characterizes IBC, suggesting that a specific molecular biology underpins this devastating disease. Here, we explore the genomic alterations underlying IBC. Methods: Mutation and copy number variation (CNV) profiles for 756 genes were assembled from 2.920 primary...