T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression

Structural abnormalities in the anterior cingulate, orbitofrontal, prefrontal and insula regions are associated with treatment non-response. These observations are not consistent in depressed adolescents. Definitions of treatment non-response are non-standardised and arbitrary, contributing to variations across studies. We aimed to classify depressed adolescents into different trajectories of symptomatic change using a data-driven approach; and...