Development of microparticles coated with poly-γ-glutamic acid to improve oral absorption of a poorly water-soluble drug

Volume: 24, Issue: 8, Pages: 992 - 1001
Published: Jun 18, 2019
Abstract
Novel microparticles coated with poly-γ-glutamic acid (PGA) were developed to improve the oral absorption of indomethacin (IM), a poorly water-soluble drug. Microparticles containing γ-IM (IMbulk-PGA) or crystal polymorph α-IM (IMpolymorph-PGA) were prepared. Additionally, microparticles were prepared containing α-IM without PGA (IMpolymorph without PGA). IMbulk-PGA and IMpolymorph-PGA exhibited better drug retention properties on mucin disks....
Paper Details
Title
Development of microparticles coated with poly-γ-glutamic acid to improve oral absorption of a poorly water-soluble drug
Published Date
Jun 18, 2019
Volume
24
Issue
8
Pages
992 - 1001
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