Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)

Published on May 20, 2019in Journal of Endocrinological Investigation
· DOI :10.1007/s40618-019-01061-2
Massimiliano Caprio25
Estimated H-index: 25
(OU: Open University),
Marco Infante2
Estimated H-index: 2
(University of Rome Tor Vergata)
+ 33 AuthorsAndrea Lenzi56
Estimated H-index: 56
(Sapienza University of Rome)
Background Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notably, there is an important lack of guidelines on this topic, and the use and implementation of VLCKDs occurs vastly in the absence of clear evidence-based indications.
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