Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis
Abstract
Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alcohol-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB1R inverse agonist JD5037 reduces ethanol drinking in wild-type mice but not in mice lacking CB1R, ghrelin peptide or GHS-R1A. JD5037 treatment of alcohol-drinking mice inhibits the formation...
Paper Details
Title
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis
Published Date
Jun 1, 2019
Journal
Volume
29
Issue
6
Pages
1320 - 1333.e8
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