Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation
Abstract
Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common heritable cancer predisposition syndrome caused by germline mutations in the NF1 tumor suppressor, which encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras proteins. Whereas most PN are clinically indolent, a subset progress to atypical neurofibromatous...
Paper Details
Title
Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation
Published Date
May 15, 2019
Journal
Volume
28
Issue
16
Pages
2752 - 2762
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