Identification of prognostic molecular biomarkers in 157 HPV‐positive and HPV‐negative squamous cell carcinomas of the oropharynx

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been increasing due to high‐risk HPV infection. We explored the significance of genetic alterations in HPV‐positive (HPV‐P) and HPV‐negative (HPV‐N) OPSCC patients on long‐term outcome. A total of 157 cases of primary resected OPSCC diagnosed from 1978 to 2005 were subjected to a targeted exome sequencing by MSK‐IMPACT™ interrogating somatic mutations in 410 cancer‐related genes....