Impact of tamoxifen (TAM) serum concentration on side effects among premenopausal patients (pts) with early breast cancer (BC) in the prospective multicenter CANTO cohort

Background: TAM causes several side effects that impact the quality of life and adherence to treatment in patients with BC. Due to the complexity of TAM metabolism, serum biomarkers predicting TAM side effects have not been identified. We hypothesized that TAM levels may be associated with side effects, thus identifying pts eligible to tailored supportive interventions. Methods: CANTO cohort (NCT01993498) is a French multicenter prospective...