Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer
Abstract
BackgroundRecurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-free circulating DNA (cfDNA) in blood and urine, or DNA from urinary exfoliated cells (cellDNA) with a single-gene sensitive assay...
Paper Details
Title
Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer
Published Date
Jun 1, 2019
Journal
Volume
44
Pages
431 - 438
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