Mild Cognitive Impairment and Decline in Resting State Functional Connectivity after Total Knee Arthroplasty with General Anesthesia

Background:Research shows that older adults can have a decline in three key resting state networks (default mode network, central executive network, and salience network) after total knee arthroplasty and that patients’ pre-surgery brain and cognitive integrity predicts decline. Objectives:First, t o assess resting state network connectivity decline from the perspective of nodal connectivity changes in a larger older adult surgery sample....