Original paper
Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Abstract
While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in ALT cancer cells, leading to apoptosis stress by activating p53-independent, but JNK/c-Myc-dependent apoptotic pathway. Notably, ALT cells expressing...
Paper Details
Title
Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Published Date
May 21, 2019
Journal
Volume
10
Issue
11
Pages
808 - 824
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Notes
History