Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases

Volume: 46, Issue: 8, Pages: 1225 - 1235
Published: Aug 1, 2019
Abstract
Engineered polyketide synthases (PKSs) are promising synthetic biology platforms for the production of chemicals with diverse applications. The dehydratase (DH) domain within modular type I PKSs generates an α,β-unsaturated bond in nascent polyketide intermediates through a dehydration reaction. Several crystal structures of DH domains have been solved, providing important structural insights into substrate selection and dehydration. Here, we...
Paper Details
Title
Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
Published Date
Aug 1, 2019
Volume
46
Issue
8
Pages
1225 - 1235
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.