Designing a high throughput multi-parameter assay for process development of antigen specific T cell therapy products

Background & Aim Infusion of viral T cells(VST) can be an effective treatment for viral infection after stem cell transplant. Current manufacturing approaches have become more rapid but are based on a few select growth conditions that have not been fully optimized. We designed a comprehensive high throughput flow cytometry-based assay for process development(PD) of VSTs that can evaluate all basic T cell characterization within one 96 well...