Ga-68-DOTA-Exendin-4 reliably detects insulinomas and shows regional differences in pancreatic distribution

Insulinomas are predominantly benign neuroendocrine tumors originating from beta cells within islets of Langerhans of the endocrine pancreas. Autonomous insulin secretion by insulinomas is the most prevalent cause for endogenous hyperinsulinaemic hypoglycaemia. Since surgical resection represents the only curative therapy for these patients, exact tumor localization and discrimination of insulinomas from focal or diffuse manifestations of...