Alterations in the gut microbiome and metabolism with coronary artery disease severity

Coronary artery disease (CAD) is associated with gut microbiota alterations in different populations. Gut microbe-derived metabolites have been proposed as markers of major adverse cardiac events. However, the relationship between the gut microbiome and the different stages of CAD pathophysiology remains to be established by a systematic study. Based on multi-omic analyses (sequencing of the V3-V4 regions of the 16S rRNA gene and metabolomics)...