Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Abstract
Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome. However, induced pluripotent stem cells (iPSC) retain transcriptional memory, epigenetic memory, and metabolic memory from their somatic cells of origin and acquire aberrant characteristics distinct from either other pluripotent cells or parental cells, reflecting incomplete reprogramming. As a critical link between the microenvironment and...
Paper Details
Title
Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Published Date
May 5, 2019
Journal
Volume
2019
Pages
1 - 10
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