Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Abstract
Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes in conjunction with molecular dynamics simulations identified a secondary CA binding site on CypA that allows a bridging interaction with two hexameric subunits...
Paper Details
Title
Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Published Date
Apr 4, 2019
Journal
Volume
16
Issue
1
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