Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine
Abstract
Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features of the resultant conjugates (PEI-DAn). We found significant differences between the PEI-DAn conjugates and conventional bPEIs with...
Paper Details
Title
Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine
Published Date
Jun 1, 2019
Volume
565
Pages
391 - 408
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