Changes in the function of angiotensin II type 1 receptor due to cholesterol depletion from cell membrane

Volume: 514, Issue: 3, Pages: 791 - 797
Published: Jun 1, 2019
Abstract
Blockers of G-protein coupled receptors (GPCRs), angiotensin II (Ang II) type 1 (AT1) receptor and β1-adrenergic (Ad) receptor, have been shown to improve the prognosis of cardiovascular disease. Cholesterol molecules in the cell membrane are needed to stabilize GPCRs as well as the cell membrane itself. We determined whether the functions of AT1 and β1-Ad receptors were changed by cholesterol depletion from cardiovascular cell membranes. Ang...
Paper Details
Title
Changes in the function of angiotensin II type 1 receptor due to cholesterol depletion from cell membrane
Published Date
Jun 1, 2019
Volume
514
Issue
3
Pages
791 - 797
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