Keratinocyte growth factor impairs human thymic recovery from lymphopenia
Abstract
The lymphocyte-depleting antibody alemtuzumab is a highly effective treatment of relapsing-remitting multiple sclerosis (RRMS); however 50% of patients develop novel autoimmunity post-treatment. Most at risk are individuals who reconstitute their T-cell pool by proliferating residual cells, rather than producing new T-cells in the thymus; raising the possibility that autoimmunity might be prevented by increasing thymopoiesis. Keratinocyte growth...
Paper Details
Title
Keratinocyte growth factor impairs human thymic recovery from lymphopenia
Published Date
Jun 20, 2019
Journal
Volume
4
Issue
12
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