Tranexamic acid-loaded chitosan electrospun nanofibers as drug delivery system for hemorrhage control applications

The work reports fabrication of hemostatic patches containing an antifibrinolytic agent with an antibacterial, hemostat polymer. Membranes were fabricated by electrospinning technique. Hemostatic membranes were characterized for swelling, morphology, mechanical, thrombosis and drug release properties. Delivery systems containing 40 mg/ml of tranexamic acid (TXA) could be successfully fabricated. Clotting time (CT) of nanofiber membranes...