Abstract GS1-03: Crosstalk between osteoblasts and breast cancer cells alters breast cancer proliferation through multiple mechanisms

BrCa preferentially metastasizes to bone, where the 5-year relative survival rate is <10%. While the mechanism for preferred metastasis is unknown, bone likely provides a hospitable environment that attracts BrCa cells (BCCs) and allows them to colonize and grow. In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Osteoclasts excavate erosion cavities and osteoblasts (OB) synthesize bone matrix, with...