Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Patch in Rats With Heart Failure

Volume: 108, Issue: 4, Pages: 1169 - 1177
Published: Oct 1, 2019
Abstract
To treat chronic heart failure (CHF), we developed a robust, easy to handle bioabsorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart covering the previously infarcted tissue.Sprague-Dawley rats (6-8 weeks old) underwent sham surgery (n = 12) or left coronary artery ligation (n = 45)....
Paper Details
Title
Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Patch in Rats With Heart Failure
Published Date
Oct 1, 2019
Volume
108
Issue
4
Pages
1169 - 1177
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