Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting
Abstract
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets. In this study, for ibuprofen tablets with high drug loading (<7% excipients), the correlations between two critical process parameters (CPPs), namely roller force during granulation and...
Paper Details
Title
Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting
Published Date
Jun 1, 2019
Volume
565
Pages
209 - 218
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