SAT-227 Diet-Induced Obesity and Prenatal Androgen Exposure Reprogram the Fetus and Cause Transgenerational PCOS-Like Phenotypic Changes in Adult Female Offspring

The fetal life is a critical window of developmental patterning affecting growth trajectories before birth and can influence the risk of reproductive and metabolic disease in adulthood. Maternal obesity and elevated prenatal androgens are two prominent potential exposures which may affect the development of the embryo and its postnatal life. If in utero androgen exposure with or without maternal obesity increase female offspring susceptibility...