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The impact of diabetes mellitus on clinical outcomes following chemotherapy for the patients with pancreatic cancer: a meta-analysis

Published on Oct 1, 2019in Acta Diabetologica2.996
· DOI :10.1007/s00592-019-01337-2
Jichun Ma (Lanzhou University), Jing Wang (SDU: Shandong University)+ 2 AuthorsJunqiang Zhang (Lanzhou University)
Abstract
Aims A meta-analysis was performed to evaluate the prognostic impact of diabetes on the clinical outcome for patients with pancreatic cancer following the adjuvant chemotherapy.
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References30
Newest
#1Jiaxin Tan (Third Military Medical University)H-Index: 4
#2Yu You (Third Military Medical University)H-Index: 5
Last. Ping Bie (Third Military Medical University)H-Index: 20
view all 6 authors...
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#1Xinghua Lv (Lanzhou University)H-Index: 1
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Background and objective Diabetes mellitus (DM) is a risk factor for pancreatic cancer but its impact on postoperative outcomes and long-term survival after cancer resection remains controversial. A meta-analysis of published studies was conducted to address this issue. Methods An extensive electronic search of four databases was performed for relevant articles. Data were processed for meta-analysis using Review Manager version 5.1. Results Seventeen observational studies involving 5407 patients...
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Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistic...
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Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11th most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied con...
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#1Phil A. Hart (The Ohio State University Wexner Medical Center)H-Index: 12
#2Melena D. Bellin (UMN: University of Minnesota)H-Index: 31
Last. Suresh T. Chari (Mayo Clinic)H-Index: 74
view all 13 authors...
Summary Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus,...
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#1Jörg KleeffH-Index: 70
Last. John P. NeoptolemosH-Index: 94
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The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer
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#1M Del Chiaro (Karolinska University Hospital)H-Index: 23
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Total pancreatectomy is associated with short- and long-term high complication rate and without evidence of oncologic advantages. Several metabolic consequences are co-related with the apancreatic state. The unstable diabetes related to the total resection of the pancreas expose the patients to short- and long-term life-threatening complications. Severe hypoglycemia is a short-term dangerous complication that can also cause patients’ death. Chronic complications of severe diabetes (cardiac and v...
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Metformin Improves Survival in Patients with Pancreatic Ductal Adenocarcinoma and Pre-Existing Diabetes: A Propensity Score Analysis
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#2Ralph H. Hruban (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 163
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Background Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance.
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#1Hui ShenH-Index: 3
#2Ming ZhanH-Index: 7
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Background: Diabetes mellitus (DM) is a risk factor for pancreatic cancer (PC), but its prognostic value in PC is still unclear. To elucidate this issue, we systematically reviewed the evidence concerning the association between diabetes status and PC. Methods: Medline and EMBASE databases were searched to identify the eligible studies. Overall and subgroup analyses were performed to detect the discrepancy of prognosis according to diabetes status. Hazard ratios (HRs) with 95% CI were used to es...
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#1Alessandro Paniccia (University of Pittsburgh)H-Index: 1
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INTRODUCTION: Neoadjuvant therapy (NT) is a growing strategy in localized head pancreatic adenocarcinoma (PDC). However, a significant portion of NT patients do not reach resection due to disease progression or performance status decline. We sought to identify predictors of disease progression or performance status decline during NT. METHODS: Retrospective cohort analysis of consecutive patients with localized head-PDC who received NT at a tertiary referral center between 2005 and 2017. Univaria...
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