The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content

It is unclear if a reduction in hepatic fat content (HFC) is a major mediator of the cardiometabolic benefit of lifestyle intervention, and whether it has prognostic significance beyond the loss of visceral adipose tissue (VAT). In the present sub-study, we hypothesized that HFC loss in response to dietary interventions induces specific beneficial effects independently of VAT changes.In an 18-month weight-loss trial, 278 participants with...