Review paper
Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease
Abstract
Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, pleiotropy robust MR methodologies.We evaluated evidence for a causal effect of...
Paper Details
Title
Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease
Published Date
May 10, 2019
Journal
Volume
14
Issue
5
Pages
e0216222 - e0216222
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