Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis
Abstract
Lung cancers have a predilection for metastasizing to bone. The matricellular glycoprotein thrombospondin (TSP)-2 regulates multiple biological functions and has a critical role in tumor development and metastasis, although its effects are uncertain in lung cancer bone metastasis. This study demonstrates that TSP-2 expression is highly correlated with lung cancer tumor stage and that the TSP-2 neutralizing antibody reduces osteoclast formation...
Paper Details
Title
Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis
Published Date
Aug 1, 2019
Journal
Volume
166
Pages
23 - 32
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