Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis

Volume: 116, Issue: 22, Pages: 11020 - 11027
Published: May 9, 2019
Abstract
Understanding the mode of action of drugs is a challenge with conventional methods in clinical trials. Here, we aimed to explore whether simvastatin effects on brain atrophy and disability in secondary progressive multiple sclerosis (SPMS) are mediated by reducing cholesterol or are independent of cholesterol. We applied structural equation models to the MS-STAT trial in which 140 patients with SPMS were randomized to receive placebo or...
Paper Details
Title
Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis
Published Date
May 9, 2019
Volume
116
Issue
22
Pages
11020 - 11027
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