MON-217 Maternal Androgen Excess and Obesity Induce Cardiac Hypertrophy and Left Ventricular Dysfunction in Female Offspring

Polycystic ovary syndrome (PCOS) is suggested to increase the risk for cardiovascular disease and type 2 diabetes. We hypothesized here that prenatal exposure to dihydrotestosterone (DHT) and/or maternal obesity lead to adverse metabolic and cardiac programming in the female offspring. The maternal obese PCOS phenotype was induced in mice by prenatal DHT exposure (PNA) combined with high-fat/high-sucrose (HFHS) diet. The female offspring were...