Benefits and harms in the National Lung Screening Trial: expected outcomes with a modern management protocol

Lung cancer screening is receiving increasing attention worldwide, both in the medical community and the general public. Multiple randomised trials—including the US National Lung Screening Trial (NLST), the Multicentric Italian Lung Detection trial, and preliminary results from the Dutch-Belgian NELSON trial— have provided definitive evidence that low-dose CT screening can reduce lung cancer mortality. However, any screening programme is...