Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.
Abstract
Neuroinflammation is considered one of the cardinal features of Alzheimer’s disease (AD). Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are surrounded by reactive astrocytes and microglia. Exposure of microglia, the resident myeloid cell of the CNS, to amyloid β causes these cells to acquire an inflammatory phenotype. While these reactive microglia are important to contain and phagocytose amyloid plaques, their...
Paper Details
Title
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.
Published Date
Apr 5, 2019
Journal
Volume
16
Issue
1
Pages
74 - 74
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Notes
History