Gestational 1-nitropyrene exposure causes gender-specific impairments on postnatal growth and neurobehavioral development in mice

Published on Sep 1, 2019in Ecotoxicology and Environmental Safety4.53
· DOI :10.1016/j.ecoenv.2019.05.016
Ran Li1
Estimated H-index: 1
(ZJNU: Zhejiang Chinese Medical University),
Xilu Wang1
Estimated H-index: 1
(Anhui Medical University)
+ 7 AuthorsDe-Xiang Xu31
Estimated H-index: 31
(Anhui Medical University)
Abstract 1-Nitropyrene (1-NP), a typical nitrated polycyclic aromatic hydrocarbon, is widely distributed in the environment and is well known for its mutagenic effects. Recently, we found that gestational 1-NP exposure induced fetal growth restriction. In this study, we further evaluated the effect of in utero 1-NP exposure on postnatal growth and neurobehavioral development in the offspring. Pregnant mice were administered with 1-NP (10 μg/kg) by gavage daily in late pregnancy (GD13-GD17). The body weight of each offspring was measured from PND1 to 12 weeks postpartum. Exploration and anxiety related activities were detected by open-field test at 6 weeks postpartum. Learning and memory were assessed by Morris Water Maze at 7 weeks postpartum. And depressive-like behaviors were estimated by sucrose preference test at 10 weeks postpartum. Significant body weight reduction was observed in 1-NP-exposed female offspring at PND1, PND14 and PND21 while the lower body weight was only found at PND1 for 1-NP-exposed male offspring. Exploration and anxiety activities at puberty, and depressive-like behavior in adulthood were not disturbed in offspring prenatally exposed to 1-NP. Interestingly, spatial learning and memory ability at puberty was impaired in females but not in males prenatally exposed to 1-NP. These findings suggest that gestational 1-NP exposure delays postnatal growth and impaired neurobehavioral development in a gender-dependent manner.
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#1Ran Li (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Xilu Wang (Anhui Medical University)H-Index: 1
Last.De-Xiang Xu (Anhui Medical University)H-Index: 31
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#1Jiayin Zhu (WMU: Wenzhou Medical College)H-Index: 1
#2Li-Yang Zhao (WMU: Wenzhou Medical College)H-Index: 1
Last.Shu-Yun Zhang (WMU: Wenzhou Medical College)H-Index: 3
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#1Kirstine Underbjerg Toxværd (DTU: Technical University of Denmark)H-Index: 2
#2Khuong Van Dinh (DTU: Technical University of Denmark)H-Index: 4
Last.Torkel Gissel Nielsen (DTU: Technical University of Denmark)H-Index: 45
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#1Mozhgan Torabi (Shahid Chamran University of Ahvaz)H-Index: 3
#2Mahnaz Kesmati (Shahid Chamran University of Ahvaz)H-Index: 5
Last.Hamid Galehdari (Shahid Chamran University of Ahvaz)H-Index: 9
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#1Jia Xie (CAS: Chinese Academy of Sciences)H-Index: 1
#2Chunfeng Zhao (Haida: Hainan University)H-Index: 2
Last.Xiaoping Diao (Haida: Hainan University)H-Index: 9
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