SAT-408 Inducible Kiss1 Knockout in the Hypothalamic Arcuate Nucleus Suppressed Pulsatile LH Secretion in Male Mice

Accumulating evidence suggests that kisspeptin/Gpr54 signaling is indispensable for GnRH/gonadotropin secretion and consequent reproductive functions in mammals. Conventional Kiss1 knockout mice and rats are reported to be infertile. To date, however, no report investigating the effect of inducible central Kiss1 knockout on pulsatile gonadotropin release is available. Here we report in vivo analysis of inducible conditional Kiss1 knockout male...