Manual and Automated Syntheses of the N-Linked Glycoprotein Core Glycans
Abstract
Presented herein are two complementary approaches to the synthesis of the core N-glycan pentasaccharide. The first, a traditional manual approach in solution, makes use of the H-bond-mediated aglycone delivery method for the highly diastereoselective introduction of the β-mannosidic linkage at room temperature. The synthesis of the core pentasaccharide was also accomplished using an high-performance liquid chromatography-assisted automated...
Paper Details
Title
Manual and Automated Syntheses of the N-Linked Glycoprotein Core Glycans
Published Date
May 8, 2019
Volume
84
Issue
11
Pages
6576 - 6588
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