Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells
Abstract
A hallmark of Alzheimer's disease (AD) pathogenesis is the accumulation of extracellular plaques mainly composed of amyloid-β (Aβ) derived from amyloid precursor protein (APP) cleavage. Recent reports suggest that transport of APP in vesicles with huntingtin-associated protein-1 (HAP1) negatively regulates Aβ production. In neurons, HAP1 forms a stable complex with Abelson helper integration site-1 (AHI1), in which mutations cause...
Paper Details
Title
Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells
Published Date
May 7, 2019
Journal
Volume
56
Issue
11
Pages
7572 - 7582
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