Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
Abstract
The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by non-programmed cell death1,2; however, how inflammation is instigated, its cellular and molecular mediators, and its therapeutic value are poorly defined. Here we use mouse models of atherosclerosis—a major underlying cause of mortality worldwide—to demonstrate that extracellular histone H4-mediated...
Paper Details
Title
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
Published Date
May 1, 2019
Journal
Volume
569
Issue
7755
Pages
236 - 240
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Notes
History