A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses
Abstract
Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much more effectively than conventional MDCK or human virus receptor-overexpressing (AX4) cells. A/H3N2 viruses propagated in hCK cells also maintained higher genetic stability than those propagated in MDCK...
Paper Details
Title
A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses
Published Date
Apr 29, 2019
Journal
Volume
4
Issue
8
Pages
1268 - 1273
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