Match!

Anatomical and functional investigation of the marmoset default mode network

Published on Dec 1, 2019in Nature Communications11.878
· DOI :10.1038/s41467-019-09813-7
Cirong Liu3
Estimated H-index: 3
(NIH: National Institutes of Health),
Cecil Chern-Chyi Yen12
Estimated H-index: 12
(NIH: National Institutes of Health)
+ 3 AuthorsAfonso C. Silva36
Estimated H-index: 36
(NIH: National Institutes of Health)
Sources
Abstract
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsolateral prefrontal cortex (dlPFC; peak at A8aD) has robust fMRI functional connectivity and reciprocal anatomical connections with the posterior DMN core regions (PPC and PCC), while the mPFC has weak connections with the posterior DMN core regions. This strong dlPFC but weak mPFC connectivity in marmoset differs markedly from the stereotypical DMN in humans. The mPFC may be involved in brain functions that are further developed in humans than in other primates.
Figures & Tables
  • References (28)
  • Citations (6)
📖 Papers frequently viewed together
10 Authors (Traian Popa, ..., Valerie Voon)
2017
126 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References28
Newest
#1Alexandre RoutierH-Index: 8
#2Arnaud MarcouxH-Index: 3
Last. Olivier ColliotH-Index: 34
view all 14 authors...
1,653 CitationsSource
#1Randy L. Buckner (Harvard University)H-Index: 127
#2Daniel S Margulies (CNRS: Centre national de la recherche scientifique)H-Index: 1
Networks of widely distributed regions populate human association cortex. One network, often called the default network, is positioned at the apex of a gradient of sequential networks that radiate outward from primary cortex. Here, extensive anatomical data made available through the Marmoset Brain Architecture Project are explored to show a homologue exists in marmoset. Results reveal that a gradient of networks extend outward from primary cortex to progressively higher-order transmodal associa...
5 CitationsSource
#1Randy L. Buckner (Harvard University)H-Index: 127
#2Daniel S. Margulies (CNRS: Centre national de la recherche scientifique)H-Index: 48
Last. Daniel S Margulies (CNRS: Centre national de la recherche scientifique)H-Index: 1
view all 2 authors...
Networks of widely distributed regions populate human association cortex. One network, often called the default network, is positioned at the apex of a gradient of sequential networks that radiate outward from primary cortex. Here extensive anatomical data made available through the Marmoset Brain Architecture Project were explored to determine if a homologue exists in marmoset. Results revealed that a gradient of networks extend outward from primary cortex to progressively higher-order transmod...
7 CitationsSource
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 3
#2Frank Q. Ye (NIH: National Institutes of Health)H-Index: 35
Last. Afonso C. Silva (NIH: National Institutes of Health)H-Index: 36
view all 7 authors...
Abstract The common marmoset (Callithrix jacchus) is a New-World monkey of growing interest in neuroscience. Magnetic resonance imaging (MRI) is an essential tool to unveil the anatomical and functional organization of the marmoset brain. To facilitate identification of regions of interest, it is desirable to register MR images to an atlas of the brain. However, currently available atlases of the marmoset brain are mainly based on 2D histological data, which are difficult to apply to 3D imaging ...
24 CitationsSource
#1Rodrigo M. Braga (Imperial College London)H-Index: 13
#2Randy L. Buckner (Harvard University)H-Index: 127
Summary Certain organizational features of brain networks present in the individual are lost when central tendencies are examined in the group. Here we investigated the detailed network organization of four individuals each scanned 24 times using MRI. We discovered that the distributed network known as the default network is comprised of two separate networks possessing adjacent regions in eight or more cortical zones. A distinction between the networks is that one is coupled to the hippocampal ...
118 CitationsSource
#1Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 12
Last. Afonso C. Silva (NIH: National Institutes of Health)H-Index: 36
view all 6 authors...
Purpose The common marmoset (Callithrix jacchus) is a New World primate of increasing interest to neuroscience and in translational brain research. The present work describes the design and implementation of individualized 8-channel receive-only radiofrequency (RF) coil arrays that provide whole-brain coverage and allow anatomical and functional MRI experiments in conscious, awake marmosets. Methods The coil arrays were designed with their elements embedded inside individualized restraint helmet...
7 CitationsSource
#1Liangtang Chang (CAS: Chinese Academy of Sciences)H-Index: 2
#2Shikun Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Neng Gong (CAS: Chinese Academy of Sciences)H-Index: 17
view all 4 authors...
Abstract Mirror self-recognition (MSR) is generally considered to be an intrinsic cognitive ability found only in humans and a few species of great apes. Rhesus monkeys do not spontaneously show MSR, but they have the ability to use a mirror as an instrument to find hidden objects. The mechanism underlying the transition from simple mirror use to MSR remains unclear. Here we show that rhesus monkeys could show MSR after learning precise visual-proprioceptive association for mirror images. We tra...
9 CitationsSource
#1Afonso C. Silva (NIH: National Institutes of Health)H-Index: 36
The common marmoset (Callithrix jacchus) is a small New World monkey that has gained significant recent interest in neuroscience research, due in great part for its compatibility with gene editing techniques, but also due to its tremendous versatility as an experimental animal model. Neuroimaging modalities, including anatomical (MRI) and functional magnetic resonance imaging (fMRI), complemented by two-photon laser scanning microscopy and electrophysiology, have been at the forefront of unravel...
18 CitationsSource
The marmoset is an emerging animal model for large-scale attempts to understand primate brain connectivity, but achieving this aim requires the development and validation of procedures for normalization and integration of results from many neuroanatomical experiments. Here we describe a computational pipeline for co-registration of retrograde tracing data on connections of cortical areas into a 3-dimensional marmoset brain template, generated from Nissl-stained sections. The procedure results in...
41 CitationsSource
#1Maryam Ghahremani (UWO: University of Western Ontario)H-Index: 2
#2R. Matthew Hutchison (Harvard University)H-Index: 22
Last. Stefan Everling (UWO: University of Western Ontario)H-Index: 34
view all 4 authors...
In contrast to the well established macaque monkey, little is known about functional connectivity patterns of common marmoset monkey (Callithrix jacchus) that is poised to become the leading transgenic primate model. Here, we used resting-state ultra-high-field fMRI data collected from anesthetized marmosets and macaques along with awake human subjects, to examine and compare the brain's functional organization, with emphasis on the saccade system. Exploratory independent component analysis reve...
35 CitationsSource
Cited By6
Newest
#1Masanori Matsuzaki (UTokyo: University of Tokyo)H-Index: 28
#2Teppei Ebina (UTokyo: University of Tokyo)H-Index: 7
The common marmoset (Callithrix jacchus), a New World monkey, is emerging as a promising animal model for biomedical and neuroscience research. This species shares its basic brain architecture, including the organization of the motor cortical areas and the connections between these and other areas, with humans and other primates. Its small and lissencephalic cerebral cortex is suitable for the application of modern biological techniques. Optogenetic stimulation of the motor cortex induces foreli...
Source
#1Toni E. Ziegler (UW: University of Wisconsin-Madison)H-Index: 49
#2Praveen Kulkarni (NU: Northeastern University)H-Index: 16
Last. Craig F. Ferris (NU: Northeastern University)H-Index: 54
view all 7 authors...
Abstract Background Novel imaging technology and procedures were developed to study brain function in preadolescent awake marmosets never exposed to anesthesia. Methods A radiofrequency transmit and receive, head only volume coil was designed and integrated into a holding system. An acclimation procedure was developed without the use of anesthesia or sedation that allowed for awake imaging. Preadolescent 8-month old male and female marmosets were imaged for resting state BOLD functional connecti...
Source
#1Yuki Hori (UWO: University of Western Ontario)H-Index: 8
#2David J. Schaeffer (UWO: University of Western Ontario)H-Index: 5
Last. Stefan Everling (UWO: University of Western Ontario)H-Index: 34
view all 8 authors...
The common marmoset (Callithrix jacchus) is a New World primate that is becoming increasingly popular as a preclinical model. To assess functional connectivity (FC) across the marmoset brain, resting-state functional MRI (RS-fMRI) is often performed under isoflurane anesthesia to avoid the effects of motion, physiological stress, and training requirements. In marmosets, however, it remains unclear how isoflurane anesthesia affects patterns of FC. Here, we investigated the effects of isoflurane o...
Source
#2Hongjun TianH-Index: 7
Last. Min Chen (Jining Medical University)H-Index: 10
view all 13 authors...
Abstract New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients were intravenously injected with ketamine six times and treated with propofol-ECT six times alternately within two weeks. The Hamilton Depression Scale was used to assess t...
Source
#1Piotr Majka (Nencki Institute of Experimental Biology)H-Index: 8
#2Sylwia Bednarek (Nencki Institute of Experimental Biology)H-Index: 1
Last. Marcello G. P. Rosa (ARC: Australian Research Council)H-Index: 48
view all 10 authors...
The rapid adoption of marmosets in neuroscience has created a demand for three dimensional (3D) atlases of the brain of this species to facilitate data integration in a common reference space. We report on a new open access template of the marmoset cortex (the Nencki-Monash, or NM template), representing a morphological average of 20 brains of young adult individuals, obtained by 3D reconstructions generated from Nissl-stained serial sections. The method used to generate the template takes into ...
Source
#1Xin GaoH-Index: 1
#2Xiaowen Xu (Tongji University)H-Index: 1
Last. Rui LiH-Index: 1
view all 6 authors...
Functional brain network (FBN) provides an effective biomarker for understanding brain activation patterns and a diagnostic criterion for neurodegenerative diseases detections. Unfortunately, it still remains challenges to estimate the biologically meaningful or discriminative FBNs accurately, because of the poor quality of functional magnetic resonance imaging data or our limited understanding of human brain. In this study, a novel FBN estimation model based on group similarity prior was propos...
Source
#1Piotr Majka (Nencki Institute of Experimental Biology)H-Index: 8
#2Shi Bai (Monash University, Clayton campus)
Last. Katrina H. Worthy (Monash University, Clayton campus)H-Index: 9
view all 14 authors...
Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by ex...
3 CitationsSource
#1Cirong Liu (University of Pittsburgh)H-Index: 1
#1Cirong Liu (University of Pittsburgh)H-Index: 3
Last. Afonso C. Silva (University of Pittsburgh)H-Index: 1
view all 11 authors...
While the fundamental importance of the white matter in supporting neuronal communication is well known, existing publications of primate brains do not feature a detailed description of its complex anatomy. The main barrier to achieving this is that existing primate neuroimaging data have insufficient spatial resolution to resolve white matter pathways fully. Here we present a resource that allows detailed descriptions of white matter structures and trajectories of fiber pathways in the marmoset...
7 CitationsSource
#1Yuki Hori (UWO: University of Western Ontario)H-Index: 8
#1Yuki Hori (UWO: University of Western Ontario)H-Index: 1
Last. Stefan Everling (UWO: University of Western Ontario)H-Index: 34
view all 8 authors...
Abstract Resting-state functional MRI (RS-fMRI) is widely used to assess how strongly different brain areas are connected. However, this connection obtained by RS-fMRI, which is called functional connectivity (FC), simply refers to the correlation of blood oxygen level-dependent (BOLD) signals across time it has yet to be quantified how accurately FC reflects cellular connectivity (CC). In this study, we elucidated this relationship using RS-fMRI and quantitative tracer data in marmosets. In add...
8 CitationsSource
Discoveries over the past two decades demonstrate that regions distributed throughout the association cortex, often called the default network, are suppressed during tasks that demand external attention and are active during remembering, envisioning the future and making social inferences. This Review describes progress in understanding the organization and function of networks embedded within these association regions. Detailed high-resolution analyses of single individuals suggest that the def...
58 CitationsSource