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Anatomical and functional investigation of the marmoset default mode network

Published on Dec 1, 2019in Nature Communications11.88
· DOI :10.1038/s41467-019-09813-7
Cirong Liu2
Estimated H-index: 2
(NIH: National Institutes of Health),
Cecil Chern-Chyi Yen11
Estimated H-index: 11
(NIH: National Institutes of Health)
+ 3 AuthorsAfonso C. Silva35
Estimated H-index: 35
(NIH: National Institutes of Health)
Abstract
The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsolateral prefrontal cortex (dlPFC; peak at A8aD) has robust fMRI functional connectivity and reciprocal anatomical connections with the posterior DMN core regions (PPC and PCC), while the mPFC has weak connections with the posterior DMN core regions. This strong dlPFC but weak mPFC connectivity in marmoset differs markedly from the stereotypical DMN in humans. The mPFC may be involved in brain functions that are further developed in humans than in other primates.
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  • References (28)
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References28
Newest
#1Cirong Liu (NIH: National Institutes of Health)H-Index: 2
#2Frank Q. Ye (NIH: National Institutes of Health)H-Index: 33
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 7 authors...
#1Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 6 authors...
#1Maryam Ghahremani (UWO: University of Western Ontario)H-Index: 2
#2R. Matthew Hutchison (Harvard University)H-Index: 20
Last.Stefan Everling (UWO: University of Western Ontario)H-Index: 44
view all 4 authors...
#1Chia-Chun Hung (NIH: National Institutes of Health)H-Index: 7
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 7 authors...
Cited By6
Newest
#1Yuki Hori (UWO: University of Western Ontario)H-Index: 1
#2David J. Schaeffer (UWO: University of Western Ontario)H-Index: 3
Last.Stefan Everling (UWO: University of Western Ontario)H-Index: 44
view all 8 authors...
#1Matthew LaClair (UMass: University of Massachusetts Amherst)H-Index: 2
#2Marcelo Febo (UF: University of Florida)H-Index: 24
Last.Agnès Lacreuse (UMass: University of Massachusetts Amherst)H-Index: 20
view all 11 authors...
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