Hybrid gel electrophoresis using skin fibroblasts to aid in diagnosing mitochondrial disease
Abstract
We developed a novel, hybrid method combining both blue-native (BN-PAGE) and clear-native (CN-PAGE) polyacrylamide gel electrophoresis, termed BCN-PAGE, to perform in-gel activity stains on the mitochondrial electron transport chain (ETC) complexes in skin fibroblasts.Four patients aged 46-65 years were seen in the Metabolic Clinic at Alberta Children's Hospital and investigated for mitochondrial disease and had BN-PAGE or CN-PAGE on skeletal...
Paper Details
Title
Hybrid gel electrophoresis using skin fibroblasts to aid in diagnosing mitochondrial disease
Published Date
Jun 1, 2019
Journal
Volume
5
Issue
3
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