Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

Aims/hypothesis The aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function. Methods Male vascular endothelial cell-specific Pdpk1 -knockout mice ( Tie2 +/− / Pdpk1 flox/flox mice) and their wild-type littermates ( Tie2 −/− / Pdpk1 flox/flox mice; control) were used for this study. At 12 weeks of age, an...