Optimizing a CRISPR-Cpf1-based genome engineering system for Corynebacterium glutamicum

Volume: 18, Issue: 1
Published: Mar 25, 2019
Abstract
Corynebacterium glutamicum is an important industrial strain for the production of a diverse range of chemicals. Cpf1 nucleases are highly specific and programmable, with efficiencies comparable to those of Cas9. Although the Francisella novicida (Fn) CRISPR-Cpf1 system has been adapted for genome editing in C. glutamicum, the editing efficiency is currently less than 15%, due to false positives caused by the poor targeting efficiency of the...
Paper Details
Title
Optimizing a CRISPR-Cpf1-based genome engineering system for Corynebacterium glutamicum
Published Date
Mar 25, 2019
Volume
18
Issue
1
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