A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
Abstract
The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic Protease-Activating Factor-1 (Apaf-1) molecules and induces cell death by activating caspase-9. Apaf-1-dependent caspase...
Paper Details
Title
A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
Published Date
May 29, 2019
Journal
Volume
9
Issue
7
Pages
1194 - 1203
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