Enzymatic reaction modulated synthesis of quantum dots for visual detection of cholinesterase activity and inhibitor

An enzyme-activable modulated synthesis of fluorescent CdTe quantum dots (QDs) strategy was developed in this work. Monitoring the in-situ growth of CdTe QDs is shown to be a novel route to label-free and visual detect butyrylcholinesterase (BChE), an important enzyme in human bodies. BChE can catalyze butyrylcholine (BTCh) to produce thiocholine (TCh), which is an excellent thio-ligand during CdTe QDs growths. Therefore, BChE can activate the...