Prion Efficiently Replicates in α-Synuclein Knockout Mice
Abstract
Prion diseases are a group of neurodegenerative disorders associated with the conformational conversion of the cellular prion protein (PrPC) into an abnormal misfolded form named PrPSc. Other than accumulating in the brain, PrPSc can bind PrPC and force it to change conformation to PrPSc. The exact mechanism which underlies the process of PrPC/PrPSc conversion still needs to be defined and many molecules or cofactors might be involved. Several...
Paper Details
Title
Prion Efficiently Replicates in α-Synuclein Knockout Mice
Published Date
Apr 30, 2019
Journal
Volume
56
Issue
11
Pages
7448 - 7457
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